Analysis of the beta-tubulin gene from Vittaforma corneae suggests benzimidazole resistance.
نویسندگان
چکیده
We amplified, cloned, and sequenced the beta-tubulin gene of Vittaforma corneae, a microsporidium causing human infections. The beta-tubulin gene sequence has a substitution at Glu(198) (with glutamine), which is one of six amino acids reported to be associated with benzimidazole sensitivity. Benzimidazoles were assayed for antimicrosporidial activity and showed poor parasite inhibition.
منابع مشابه
Analysis of the -Tubulin Gene from Vittaforma corneae Suggests Benzimidazole Resistance
Microsporidia are obligate intracellular protozoan parasites that have emerged as major opportunistic human pathogens since the onset of the AIDS pandemic (6, 11). Vittaforma corneae is responsible for keratitis in otherwise healthy persons (2, 9, 10, 18), but disseminated infections have occurred in human immunodeficiency virus-infected patients as well (3). V. corneae was first described as N...
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ورودعنوان ژورنال:
- Antimicrobial agents and chemotherapy
دوره 52 2 شماره
صفحات -
تاریخ انتشار 2008